Later On

Dean and Sam and Elena are preparing explosives with rags and glass bottles. Dr. Lee enters, hands in her pockets.

"It's been over four hours. Duane's blood is still clean. I don't think he's infected. I'd like to untie him, if that's all right." Dr.Lee Says as They all share a look Sam and Elena nods while Dean lowers his head.

"Sure. Yeah. she then leaves, You know I'm gonna ask you why." Sam Says

"Yeah I know" Dean Says

"So why? Why didn't you do it?" Elena Asks

"We need more alcohol." Dean Says as Sam gets up and goes into the dispensary and finds Pam is already there.

"How you holding up, Pam?" Sam Asks

"Good. It'll all be over soon." Pam Says As She shuts the door and locks it; Sam, his back turned, doesn't notice. In fact, I've been waiting for this the whole time."

"For what?" Sam Asks

"To get you alone." Pam Says As She lashes out and knocks him to the ground. She straddles his chest and hits him, hard, across the face. Outside the room, Dean and Elena hear the commotion and arm themselves. Pam has a scalpel in one hand, which she slices across Sam's chest and then across her own palm, placing her wound over his. Dean kicks the door open and he and Elena shoots her several times in the back. She convulses and falls to the floor. Sam reaches out a hand to Dean, who starts to lean over to take it; Elena pulls him back.

"She bled on him. He's got the virus." Elena Says

Sam pulls his hand back, realizing it's true; close on Dean face, stunned, looking from Sam to Pam.

___________________________________
THE LAB

Sam is now sitting on the stool, a bandage pressed to his chest. His eyes are down, and he looks near tears. The others surround him, Dean is pacing angrily.

"Doc, check his wound again, would you?,Doctor!" Dean Says

"What's she need to examine him for? You saw what happened." Mark Says

"Did her blood actually enter your wound? Dean Asks

"Come on, of course it did! You and your partner saw it for yourselves " Mark Says

"We don't know that for sure." Dean Says

"We can't take a chance." Duane Says

"You know what we have to do." Mark Says

"Nobody is shooting my brother." Dean Says

"He isn't gonna be your brother much longer. You said it yourself." Duane

"Nobody is shooting anyone!,Okay." Elena Says

"He was gonna shoot me!" Duane Says

"You don't shut your pie-hole, I still might!" Dean Says as Elena puts a hand on his chest to back him up

"Guys, they're right. I'm infected; just give me the gun and I'll do it myself." Sam Says

"Forget it." Dean and Elena Says

"Guys, I'm not gonna become one of those things.

"Sam, we've still got some time," Dean Says

"Time for what? Look, I understand he's your brother, and I'm sorry, I am. But we gotta take care of this." Mark Says As He pulls out his handgun.

"I'm gonna say this one time — you make a move on him, you'll be dead before you hit the ground. You understand me? I mean, do I make myself clear?!" Dean Says

"Then what are we supposed to do?!" Mark SaysAs Dean tosses Mark his keys.

"Get the hell out of here, that's what. Take my car. You've got the explosives, there's an arsenal in there. You two go with him. You've got enough firepower to handle anything now." Dean Says

"What about you?" Mark Asks

"Dean, Elena No. Go with them. This is your only chance!" Sam Says

"You're not gonna get rid of me that easy." Dean Says

"And I wouldn't leave without you guys" Elena Says

"No, he's right. Come with us. Okay, it's your funeral." Mark Says As He leads Duane and Dr.Lee out the door.

"I'm sorry. Thanks for everything, Marshals." Dr.Lee Says

"Oh, actually we're not really Marshals." Elena Says

"Um. Oh."Dr.Lee Says ,She leaves, and Dean shuts the door behind her. He turns slowly to face Sam and Elena, Sam starts to cry.

"Wish we had a deck of cards, or a foosball table or something." Dean Says

"Dean and Elena please, don't do this. Just get the hell out of here." Sam Says

"No way." Elena Says

"Give me my gun, and leave." Sam Says

"For the last time, Sam. No." Dean Says

He Slams his hands on the table,"This is the dumbest thing you've ever done. Both of you" Sam Says

"Ehh that's debatable" Elena Says as she shrugs her shoulders

"Oh, I don't know about that. Remember that waitress in Tampa?" Dean Says

"Guys I'm sick. It's over for me. It doesn't have to be for you." Sam Says

"No?" Dean Says

"No, you can keep going." Sam Says

"Who says I want to?" Dean Says

"What?" Sam and Elena Asks As Dean crosses to the other wall and pulls a handgun out of his waistband before sitting on the file cabinet.

"I'm tired, Sam. I'm tired of this job, this life . . . this weight on my shoulders, man. I'm tired of it." Dean Says

"So what, so you're just going to give up? You're just gonna lay down and die? Look, Dean, I know this stuff with Dad has —" Sam Says

"You're wrong. It's not about Dad. I mean, part of it is, sure, but . . ." Dean Says

"What is it about?" Elena Asks As They hear a noise outside; a moment later there's a knocking on the door. Dean picks up both handguns and crosses to it; Dr.Lee is there. He opens the door.

"You'd better come see this." Dr.Lee Says

All five survivors are standing just outside the clinic; everything else in sight is deathly silent.

"There's no one. Not anywhere. They've all just . . . vanished." Dr.Lee Says Then Close shot of a telephone pole into which is carved "CROATOAN".

In The Lab, Dr.Lee is looking through the microscope; Sam is seated on the exam table.

"Well, it's been five hours and your blood's still clean. I don't understand it but I think you dodged a bullet." Dr.Lee Says

"But I was exposed. How could I not be infected?" Sam Asks

"I don't know. But you're just not. I mean, you compare it with the Tanner samples . . she looks through another microscope, What the hell?" Dr.Lee Says

"What?"Sam Asks

"Their blood. There's no trace of the virus. No sulfur, nothing." Dr.Lee Says

___________________________________

Mark and Duane are loading up a truck Dr.Lee stands in the doorway of the clinic.

"Hey, the Sarge and I are getting the hell out of here, heading south. You should come." Duane Says

"I'd better get over to Sidewinder, get the authorities up here. If they'll believe me. Take care." Dr.Lee Says
Mark waves to her and to Dean and Sam and Elena, who are leaning against the Impala.

"What about him?" Dean Says

"He's going to be fine. No signs of infection." Dr.Lee Says As Dr.Lee goes back inside as Mark and Duane pull away in the truck. Dean turns to Sam.

"Hey man, don't look at me. I got no clue." Sam Says

"I swear, I'm gonna lose sleep over this one. I mean, why here, why now? And where the hell did everybody go? It's like they just friggin' melted." Dean Says

"Why was I immune?" Sam Asks

"Yeah. You know what? That's a good question. You know, I'm already starting to feel like this is the one that got away?" Elena Says As They get in the car and pull away from town.

__________________________________

Mark drives his pickup down a dark two-lane road; Duane is in the passenger's seat.

"You mind pulling over up ahead there?" Duane

"All right." Mark Says As He pulls onto the shoulder and stops the truck.

"I gotta make a call." Duane Says

"No phone out here." Mark Says

"I got it covered." Duane Says As He pulls out a small knife.

"What the hell is that?" Mark Asks, In a quick motion, Duane lashes out, slitting Mark's throat; he catches the blood in a metal bowl, He sits back and dips his hand in the blood, swirling it around.

"It's over, you'll be pleased. I don't think any more tests are necessary. The Winchester boy, definitely immune, as expected. Yes, of course. Nothing left behind." Duane Says as his eyes have gone demonic-black.

__________________________________
BRIDGE

The Impala is parked by the side of a road, overlooking a river. Dean and Sam and Elena lean against a fence, drinking beer.

"So. Last night. You want to tell me what the hell you were talking about?" Sam Says

"What do you mean?" Dean Says

"What do I mean? I mean you said you were tired of the job. And that it wasn't just because of Dad." Sam Says

"Forget it." Dean Says

"No, I can't. No way." Sam Says

"Come on man, I thought we were both going to die, you can't hold that over me." Dean Says

"No, no, no, no. You can't pull that crap with us, man. You're talking." Elena Says

"She's Right, now talk" Sam Says

"And what if I don't?" Dean Asks

"Then I guess I'll just have to keep asking until you do." Sam Says

"Or... I could Make him talk trust me I have my ways of getting people to talk" Elena Says then she smirks

"Uh Uh if it involves you doing things to me I'm good" Dean Says as she rolls her eyes at him

"Just Talk Man" Sam Says

"I don't know, man. I just think maybe we ought to . . . go to the Grand Canyon." Dean Says

"What?" Sam Asks

"Yeah, you know, all this driving back and forth across country, you know I've never been to the Grand Canyon? Or we could go to T.J. Or Hollywood, see if we can bang Lindsey Lohan."

"You're not making any sense" Sam Says

"Yeah and Lindsey Lohan is way to young for you" Elena Says

"I just think we should take a break from all this. Why do we gotta get stuck with all the responsibility, you know? Why can't we live life a little bit?" Dean Asks

"Why are you saying all this?" Elena Asks As Dean Shakes his Head then he turns away

"No, no, no, no, Dean. You're my brother, all right? So whatever weight you're carrying, let me help a little bit." Sam Says

"I can't. I promised." Dean Says

"Who?" Sam Asks

"Dad." Dean Says

"What are you talking about?" Sam Asks

"Right before Dad died, he told me something.
takes a breath, then looks at Sam,He told me something about you." Dean Says

"What? Dean, what did he tell you?" Sam Asks