The osler medical handbook -john hopkin
Section VIII – Infectious DiseasesSection Editors:Christopher Hoffmann, MD, MPH Nicola Zetola, MDChapter 53 – Fever of Unknown OriginScott Kim, MD Rachel Damico, MD, PhD Paul Auwaerter, MDFAST FACTS ▪ The contemporary understanding of fever of unknown origin (FUO) is derived from Petersdorf and Beeson's 1961 characterization of FUO. A stringent definition of FUO is composed of the following criteria[1]: temperature higher than 38.3° C measured on several occasions, 3-week duration (to exclude self-limiting fevers), negative blood cultures, no apparent explanation, and three outpatient visits or three hospital days. ▪ Infections, malignancies, and noninfectious inflammatory diseases account for the majority of cases of FUO. ▪ In patients older than 65 years, temporal arteritis should be considered early in any evaluation. ▪ Patients with FUO who remain undiagnosed after exhaustive study usually have a favorable prognosis. In one study, in a cohort of 61 patients with FUO discharged without diagnosis, the 5-year mortality rate was only 3.2%.[2]…



![[OG][CV][Xử Nữ - Thiên Yết] Sủng Ái Cả Đời](https://truyen247.pro/images/og-cv-xu-nu-thien-yet-sung-ai-ca-doi-358540298.webp)



![[ Winner ] [ MinWoo ] - Anh Là Của Tôi](https://truyen247.pro/images/winner-minwoo-anh-la-cua-toi-200247365.webp)


![[TF Gen 2] Mental Baja, Dompet Merana ⛈️](https://truyen247.pro/images/tf-gen-2-mental-baja-dompet-merana-405463603.webp)