Male Reader as The Molten Man

Willem Dafoe as Norman Osborn/Green Goblin

Zendaya as MJ (Michelle Jones)

Jacob Batalon as Ned Leeds

Tom Holland as Peter Parker/Spider-Man

Jamie Foxx as Maxwell Dillon/Electro

Thomas Haden Church as Flint Marko/Sandman

Rhys Ifans as Curt Conners/Lizard

Alfred Molina as Doctor Otto Octavius/ Doctor Octopus

And Others.