First I'm going to say that I haven't read any of the comics so if I'm wrong about anything here I apologize. Seriously people, honestly I like both Spiderman and Deadpool but I don't ship them. Even if they've met in the comics and  Wade is pansexual it never says that Peter is. As far as I know, even in the comics Peter is always put with girls. just because their suits are both red it doesn't mean that you should ship them.

Keep in mind though I have only ever seen the movies so if anything I used as reasons are wrong I didn't know.  my opinion on Marvel ships are based completely on what I've seen in the movies.