Vilgax: The conqueror of planets seeks to defeat his archenemy Ben 10 and the Shinkengers so he can conquer the earth once and for all.

Thanos: The mad titan seeks to wipe out half of the Earth's population by collecting the infinity gems.

Gedoshu: Gedoshu and their allies, the Ayakashi seek to conquer both Earth and Remnant, and only the Shinkengers can stop them.

Black Order: Thanos' most faithful servants, they seek to help their leader to achieve his plans.