Here are the villains Spidey will be facing:
-Green Goblin (Spidey's True Archenemy)

-Sinister Six (Rhino, Vulture, Electro, Doc Ock (Leader), Shocker and Scorpion)

-Mister Negative

-Sandman

-Mysterio

-Kraven

-Lizard (Becomes good later on!)

-Venom (Host: Eddie Brock! Has desertion issues! Eventual Anti-Hero! Love brains...and chocolate)

-Carnage (Host: Cletus Kassidy! Venom 2.0! Complete psychopath! Loves killing and infecting people!)

-And more where that came from!