Ephraim=Leader of the Sanctuary he has two young daughters Angel and River.
Species:Warlock

Angel and River=Species:Witches
Angel and River saved Prince Kato's life and performed powerful magic for two so young.

Jefferson=Species Warlock  Jefferson was once reckless until he saved a young Witch and started to care for her.

Maria=Species Witch Maria was rescued and taken in by Jefferson she is the reason and cause of his change in character.

The vampires

Dante Santiago= A close friend of Ephraim he also protects Angel and River from Outsiders. Dante becomes a love interest of Meredith and seems to be faithful.

Felix May= A vampire who is known to be affectionate and needy and seems to get a kick out of getting bit. Felix likes attention from any supernatural.

Luna Coral= A Bisexual teenaged vampire who seems to have the hots for a werewolf and Demon at the Sanctuary.

Lori= Lori was turned by an unknown vampire and her views of humans are quite different to her fellow vampires she seems to adore anything to do with humans.

Werewolves

Adrianna Blayke= Beta Adrianna is a love interest of Lunas but she has compition from a certain Demon.

Keller Morales=Alpha Keller is intrigued by Faidon being a Hybrid. Kelller can speak many languages.

Other supernaturals

Addison= Phoenix Addison is the only female Phoenix left she becomes a younger sister to Morgan.

Christian= Phoenix Christian is hot headed at times but will do anything for members of the Sanctuary.

Lillian= Demon Lillian is the first Demon we have seem to show emotions other than hate.

Gabe=Angel Gabe becomes a good friend to Meredith.

Sofia=Angel Sofia is quite shy she seems to also adore humans like Lori.

Harvell=psychic Harvell can see the future.

Blake= Dhampir Blake is half human half vampire he also works as a high school teacher at a human school.