Robert Downey Jr as Anthony "Tony" Edward Stark / Iron Man 

Mark Ruffalo as Robert "Bruce" Banner / The Incredible Hulk

Elizabeth Olsen as Wanda Django Romanoff (née Maximoff)
/ Scarlet Witch

Chris Evans as Steven "Steve" Grant Rogers / Captain America

Scarlett Johansson as Natasha Ingrid Romanoff / Black Widow

Chris Hemsworth as Thor Odinson

Tom Holland as Peter Benjamin Parker / Spider Man

Zendaya Coleman as Michelle Julie "MJ" Parker (née Stark)/ Spinneret

Florence Pugh as Yelena Fyodorovna Romanoff / White Widow

Anthony Mackie as Samuel Thomas Wilson / The Falcon

Emily Vancamp as Sharon Carter / Agent Thirteen

Sebastian Stan as James Buchanan “Bucky” Barnes / Winter Soldier

Halle Bailey as Elizabeth "Liz" Osborn (née Allan) / Agent Liz

Mitchell Hope as Harold Theopolis "Harry" Osborn  / Agent Harry

Elle Fanning as Gwen Stacy Morales (née Stark) / Spider Ghost

Justice Smith as Miles Gonzalo Morales / Arachnid

Diego Boneta as Miguel O'Hara / Spider Man 2099

Jung Ho-yeon as Cindy Moon / Silk

Don Cheadle as James Rupert "Rhodey" Rhodes / War Machine

Josephine Langford as Felicia Sara Thompson (née Hardy) / Black Cat

Tony Revolori as Eugene "Flash" Thompson / Anti Venom

Emily Deschanel as Mary Teresa Parker (née Fitzpatrick) / Agent Mary

David Boreanaz as Richard Laurence Parker  / Agent Richard

Keanu Reeves as Benjamin "Ben" Franklin Parker / Agent Ben

Samuel L. Jackson as Nicholas "Nick" Joseph Fury

Riele Downs as Billie Mariana Morales / Agent B

Millie Bobby Brown as Teresa Elizabeth Parker / Agent T

Alexa Ilacad as Morgan Stark II / Agent M

Johnny Depp as Morgan Stark

Jessica Alba as Nurse Rio Morales

Isaiah Mustafa as Officer Jefferson "Jeff" Morales

Jennifer Connelly as Virginia Stark
(née Pym)

Paul Bettany as Vision Shade Stark / The Vision

Willa Fitzgerald as Crystalia "Crystal" Maximoff

Donald Glover as Aaron Davis

Ryan Reynolds as Wade Wilson / Deadpool

Emma Fuhrmann as Cassandra "Cassie" Eleanor  Lang / Agent C

And more